Clinical studies showed promising results in patients with bullous pemphigoid, C1-INH-AAE, Castleman's disease, idiopathic nephrotic syndrome, Goodpasture's syndrome, IgG4-related disease, juvenile idiopathic arthritis, myasthenia gravis, and spondyloarthropathy. This evidence concerns the gene SERPING1 and immunoglobulin G4-related sclerosing disease.