Clinical studies showed promising results in patients with bullous pemphigoid, C1-INH-AAE, Castleman's disease, idiopathic nephrotic syndrome, Goodpasture's syndrome, IgG4-related disease, juvenile idiopathic arthritis, myasthenia gravis, and spondyloarthropathy. The gene discussed is SERPING1; the disease is anti-glomerular basement membrane disease.