Moreover, other key enzymes involved in glycolysis and mitochondrial respiration are reduced in CD4+ T cells from RR-MS subjects, such as aldolase, hexokinase 1, Glut1, dihydrolipoamide S-acetyltransferase (DLAT), and dihydrolipoamide S-succinyltransferase (DLST); interestingly, restoration of these enzymes after IFN-β-1a treatment correlates with disease amelioration (165). Here, DLST is linked to myeloid sarcoma.