Targeted DNA methylation profiling of cardiac tissue from patients with dilated cardiomyopathy revealed hypomethylation and significantly elevated gene expression of matrix metalloprotease 2 (MMP2) and connective tissue growth factor (CTGF), two genes important for the turnover and stability of the extracellular matrix (ECM) (61). Here, CCN2 is linked to dilated cardiomyopathy.