For instance, loss-of-function mutations in the COA8 gene (alias APOPT1, APOP-1, or C14ORF153) have been identified in seven subjects from six different families presenting a distinctive form of mitochondrial encephalopathy (Melchionda et al., 2014; Sharma et al., 2018). This evidence concerns the gene COA8 and Mitochondrial encephalopathy.