For the first time, the results of this study ultimately proved that the FX isolated from C. weissflogii ND-8 with the yield of 6 mg/gdw, and protected the mice against LPS-induced sepsis death with the survival rate from 0% to 40%, as well as FX showed dose-dependent inhibition against LPS-induced pro-inflammatory factor IL-6 production (IC50 = 2.19 ± 0.70 μM) via significantly does-dependently inhibited the LPS induced the upregulated expression of phosphor-IκBα and phosphor-NF-κB in RAW264.7 cells. Here, IL6 is linked to Sepsis.