BACE1 and Alzheimer disease: ADAM10, Beta-secretase 1 (BACE1), nicastrin, and presenilin 1 and 2 (PSEN1 and 2) are other examples of AD pathogenic proteins found inside exosomes of transgenic mouse brain (Tg2576) and cell culture APP models, as CHO cell line (Sharples et al., 2008; Perez-Gonzalez et al., 2012).