Goetzl et al. (2015, 2018) measured the levels of different pathogenic proteins, Aβ-amyloid, total tau and p-tau isoforms inside NDEs immunoprecipitated with L1CAM to isolate specifically neuronal exosomes from blood of AD, Mild Cognitive Impairment (MCI) and controls (Kapogiannis et al., 2015). This evidence concerns the gene MAPT and Cognitive impairment.