DJ-1, a sensor of oxidative stress (Canet-Avilés et al., 2004), can decrease the accumulation and toxicity of α-synuclein in PD models (Shendelman et al., 2004; Zhou et al., 2011; Sun et al., 2012; Zondler et al., 2014; Lee et al., 2017). This evidence concerns the gene PARK7 and Parkinson disease.