For example, CRP has been found in neurofibrillary tangles and neuritic plaques in brains of people with AD (Duong et al., 1997), and soluble CD40 has been shown to be elevated in plasma of people with AD (Mocali et al., 2004; Ait-ghezala et al., 2008; Doecke et al., 2012) and predictive of progression to AD (Buchhave et al., 2009). This evidence concerns the gene CD40 and Alzheimer disease.