Because the spatial distribution of MyHC profiles in the intrinsic tongue is anticipated to be of functional significance (Stål et al., 2003), has been shown to change with aging (Cullins and Connor, 2017), and DS is associated with hallmarks of age-related functional decline (Wisniewski et al., 1978), future studies evaluating the spatiotemporal distribution of myofiber types in the intrinsic tongue in mouse models of DS may support improved understanding of functional changes in tongue movement across the lifespan in DS. Here, MYH6 is linked to Dravet syndrome.