In addition, transgenic mice harboring the G2019S (glycine to serine substitution at amino acid 2019) mutation have been shown to display anxiety/depression-like behavior, despite the paradoxical phenotype of G2019S mutation gain of function and loss of LRRK2 in KO mice (Lim et al., 2018). The gene discussed is LRRK2; the disease is depressive symptom measurement.