Fujikawa et al. (2015) have investigated the association between EGCs and gastrointestinal dysmotility in maternally separated rats (Fujikawa et al., 2015). Also, a lower level of glial fibrillary acidic protein (GFAP) phosphorylation has been observed in colonic biopsy samples from PD patients (Clairembault et al., 2014). Given that neurons and EGCs comprise a huge complex circuit, and that astroglia express LRRK2 in the CNS, it is important to further analyze the ENS structure of LRRK2-KO mice, including their degree of EGC complexity (Coelho-Aguiar et al., 2015). Here, LRRK2 is linked to Parkinson disease.