MAPT and Alzheimer disease: We utilized a cohort of aging vervet monkeys (Chlorocebus aethiops sabaeus), which develop neuropathological changes consistent with human AD pathology including increased amyloid plaque burden, elevated cortical tau levels and paired helical filament tau immunoreactivity, Aβ-related vascular impairment, reduced cerebral metabolism, regional atrophy, decreased CSF Aβ42 and increased CSF tau levels (Kalinin et al., 2013; Chen et al., 2018; Latimer et al., 2019), to ensure translational relevance of our findings.