We previously demonstrated that hyperglycemic APP/PS1 mice, a model of cerebral amyloidosis, have elevated Aβ within the brain’s ISF (Macauley et al., 2015; Stanley et al., 2016), and non-human primates with T2D have increased Aβ deposition in several brain regions (Okabayashi et al., 2015). This evidence concerns the gene APP and type 2 diabetes mellitus.