Aged monkeys (>19 years) can develop pathology consistent with human AD including increased amyloid plaque burden, elevated cortical tau levels and paired helical filament tau immunoreactivity, Aβ-related vascular damage, reduced cerebral metabolism, regional atrophy, and alterations in CSF biomarkers including both Aβ and tau (Kalinin et al., 2013; Chen et al., 2018; Latimer et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.