Chemokine and cytokine signaling pathways, the TNF signaling pathway and apoptosis-related pathways were enriched in the set of genes upregulated in Nfkb2−/− Tregs, while primary immunodeficiency related pathways, hematopoietic cell-lineage pathways, and the NF-κB pathway were enriched in the downregulated gene set. Here, TNF is linked to inborn error of immunity.