A link of GRK2 to medulloblastoma was hypothesized by Sengupta et al., who identified a subgroup of SHH medulloblastomas characterized by CXCR4 activation, showed that CXCR4 and SHH pathways functionally interact, and proposed that SHH may affect CXCR4 signaling via regulation of GRK293. Here, SHH is linked to medulloblastoma.