NLRP3 and type 2 diabetes mellitus: It has been postulated that the NACHT, LRR and PYD domains-containing protein 3 (Nlrp3) inflammasome is responsible for the inflammation that leads to the development of T2D in obese animals, as Nlrp3 deficient obese animals showed a lower degree of IR than wild type (Wt) obese animals3,6.