CASP1 and Glucose intolerance: The reduction in glucose intolerance and improved insulin sensitivity observed in the Nlrp1b1-transgenic mice relative to Wt C57BL/6 mice, correlated with a clear reduction in the inflammatory process triggered by the HFD in the adipose tissue (reduced cellular infiltrated and reduced caspase-1 activation) which correlated with lower blood IL-1β levels compared with Wt C57BL/6.