According with our hypothesis, transgenic mice expressing the Nlrp1b1 allele in a C57BL/6 background, which endogenously carry the Nlrp1b2 allele, showed reduced glucose intolerance and improved insulin sensitivity when fed with a HFD despite the fact that they gained the same weight than Wt C57BL6/ mice. Here, INS is linked to Glucose intolerance.