Taking this into consideration and that mice deficient for the three alleles of the Nlrp1 gene (Nlp1a, Nlrp1b and Nlrp1c) develop obesity and metabolic syndrome10 we hypothesized that Nlrp1b1 inflammasome may negatively modulate lipid-induced Nlrp3-mediated inflammation and obesity-related metabolic alterations. Here, NLRP3 is linked to obesity due to melanocortin 4 receptor deficiency.