Along this line, PHF8 has been documented in cell culture systems as a MYC transcriptional coactivator35 and a regulator of prostate cancer cell proliferation, migration and invasion36,43, supporting the idea that an incremental gain in PHF8 activity by HFD at H4K20me1 might provide increased tumour fitness over the course of prostate cancer development. Here, PHF8 is linked to Familial prostate cancer.