Interestingly, when compared with ALK-driven HGG, low-grade ALK gliomas tended to be diagnosed at an older age (median = 5.0 versus 1.6 months) and showed a better clinical outcome; all patients with ALK-fused LGG (n = 5) were alive at a median follow-up of 5 years (range, 1.4–7.2 years), whereas 42.9% (3/7) patients with ALK-fused HGG were deceased at a median follow-up of 3 years (range 0.01–8.55 years). This evidence concerns the gene ALK and central nervous system cancer.