Interestingly, commonly downregulated genes included c-Myc and c-Myc target genes, as well as additional pro-oncogenic factors, such as IL1B, NT5E (CD73), and other molecules with functions in tumor immune escape (Fig. 6d, Supplementary Tables 6 and 7)38,39, which were validated by qPCR (Supplementary Fig. 10C). The gene discussed is IL1B; the disease is neoplasm.