TWIST1 and cancer: Moreover, in agreement with previous reports, WT1 activity was significantly higher in ovarian serous25 and uterine sarcoma26; TWIST1, a central player in the EMT, had increased activity in ovarian serous27 and uterine serous cancers; YY1, which regulates various processes of development and differentiation and is involved in tumorigenesis of breast and ovarian cancer28, had increased activity in these cancers.