Importantly, most differentially expressed genes (DEGs) identified in MDA-MB-436 upon MITF suppression correlated with PSIONIC-inferred MITF activity across multiple basal breast cancer cell lines (n = 29; 75 out of 161 DEG, ~47%, |ρ| > 0.4, Fig. 6e) as well as across patient samples (n = 92; 43 out of 161 DEG, ~27%, |ρ| > 0.4). The gene discussed is MITF; the disease is breast carcinoma.