SH2B3 and hypertensive disorder: We also explored the association between our sentinel variants and their proxies with other traits from published GWASs using Phenoscanner.14 The variants in the SH2B3 locus for LVEDV was associated with multiple risk factors that could mediate the cardiac remodeling process such as blood pressure/hypertension, cholesterol/low-density lipoprotein level, diabetes mellitus, and smoking status.