Another potential candidate gene at the same locus is NMB (neuromedin B), which is associated with regulation of eating behavior and obesity.44 This gene has previously been highlighted as a candidate gene in a GWAS investigating the ECG indices of LV hypertrophy,45 in which the sentinel variant was moderately correlated (LD r2=0.39) with our LVMVR sentinel variant. This evidence concerns the gene NMB and obesity due to melanocortin 4 receptor deficiency.