GRK5 regulates cardiac development through the mammalian target of rapamycin (mTOR) pathway in zebrafish.34,35 Its expression level in the myocardium is elevated in heart failure, and a nonsynonymous polymorphism of GRK5 appears to be protective of heart failure through inhibition of β-adrenergic receptor signaling.36,37 In addition, GRK5 is a known drug target for β-blockers and antihypertensive agents (Table XIV in the online-only Data Supplement). The gene discussed is GRK5; the disease is heart failure.