The current study showed decreased in PTEN expression in breast tumor tissue in only 16% of patients compared to expression in normal breast tissue, which was similar to Palimaru et al study (Palimaru et al., 2013), it has been reported that low of PTEN mRNA expression in breast carcinoma tissue occurs in only 20% of patients compared to normal breast tissue. The gene discussed is PTEN; the disease is breast carcinoma.