Other studies showed that the down-regulation of miRNA-145 in human lung adenocarcinoma was associated with EGFR amplification and its transfection inhibited cancer cell growth through the suppression of its targets, EGFR and NUDT-1 (Cho et al., 2011; Seshacharyulu et al., 2012). This evidence concerns the gene NUDT1 and lung adenocarcinoma.