EGFR and neoplasm: EGFR signaling triggers a network of signaling cascades, including the phosphoinositide (PI3K) pathway, Akt kinase pathway, STAT signaling pathway, Ras/Raf/MEK/ERK1/2 pathway, and the phospholipase C gamma protein pathway, which promotes tumor cell proliferation, invasion, survival, angiogenesis, metastasis and apoptosis resistance (Yoshida et al., 2010; Seshacharyulu et al., 2012; Kumarakulasinghe et al., 2015).