POU5F1 and lung cancer: Other studies showed that miRNA-145 expression reduced in lung cancer cells, causing elevated c-MYC, NUDT1, OCT4 and EGFR expression, increased tumor cell proliferation, metastasis and migration (Liu et al., 2009; Chen et al., 2010; Cho et al., 2011; Yin et al., 2011; Guan et al., 2012).