They showed that extracellular acidity activates the upregulation of sterol regulatory element-binding protein-2 (SREBP2), a transcriptional regulator of cholesterol biosynthetic enzymes, by which acyl-CoA synthetase short-chain family member 2 (ACSS2), a direct SREBP2 target, promotes tumor growth and progression in pancreatic cell lines. Here, ACSS2 is linked to neoplasm.