Spearman’s rank correlation revealed that in cirrhosis group, there was a negative correlation between miRNA-215 level and serum AFP level (rs= -0.27; p<0.020) as illustrated in Figure 1 and in HCC group, there was a negative correlation between MiRNA-215 level and serum AFP level, (rs= -0.72; p<0.001) as illustrated in Figure 2. This evidence concerns the gene AFP and hepatocellular carcinoma.