In present study, we have assessed the role of GSTs polymorphism with association to lung cancer risk with three polymorphic genotypes of GSTT1, GSTM1, and GSTP1. Our findings suggested that the GSTT1 holds positive association towards lung cancer risk whereas GSTM1 and GSTP1 showed no association to lung cancer risk in this study. This evidence concerns the gene HPGDS and lung cancer.