Tumor angiogenesis is coordinated by a synchronized increase in the expression of genes, including VEGF, IL-8 and IL-6, acidic as well as basic fibroblast growth factor (FGF), angiopoietins and the hypoxia-inducible factor 1 alpha (HIF-1α), with downregulation of endogenous angiogenesis inhibitors such as: endostatin, thrombospondins, interferon and angiostatin (Hanahan and Folkman, 1996). Here, HIF1A is linked to neoplasm.