Statistical analysis of the correlations between the different studied parameters (Tables 5, 6, 7) demonstrated positive correlation between TOC and IL18( r= 0.731, P= 0.002) and between TAC and NO (r= 1.000, P=0.04) in the benign group B, however there where negative correlation between TOC and each of TAC and NO (r=-0.648, P= 0.009 and r-0.646, P=0.008 respectively) in the newly diagnosed group N. Positive correlation between TAC and NO occurred while studying the correlation between the laboratory parameters in the whole N+M cancer group. Here, IL18 is linked to cancer.