CSF2 and neoplasm: Interleukin-18 (IL-18) is an immunoregulatory cytokine that has multiple biologic functions such as promoting the production of granulocyte macrophage colony stimulating factor, IL-2 and activating NK cells and macrophages (Ling et al., 2011) The production of IL-18 may be induced in response to tumor cells or other factors related to tumor growth (Günel et al., 2003).