IL18 and cancer: Several cancers including bladder cancer (Jaiswal et al., 2013) and ovarian cancer (Samsami et al., 2009) and gastrointestinal cancer (Haghshenas et al., 2009) showed higher levels of IL-18.IL 18 and its receptor (IL18 R) expression in were found to have a role in ovarian epithelial cells either cancerous or normal (Medina et al., 2014).