In an experimental study, Isobe et al. investigated the potential role of Ang II in the proliferation of rat ELT-3 leiomyoma cells (Eker rat uterine leiomyoma-derived smooth muscle cells) in vitro and found that Ang II significantly induced ELT-3 leiomyoma cell proliferation and the expression of AGTR1 and AGTR2 mRNA and protein was confirmed. This evidence concerns the gene AGTR1 and leiomyoma.