When stratified by ethnicity, there was a significant association between the MTHFR 677C>T polymorphism and an increased risk of ovarian cancer in Asians under all five genetic models, i.e., allele (T vs. C: OR = 1.132, 95% CI 1.259-1.772, p ≤0.001), homozygote (TT vs. CC: OR = 1.212, 95% CI 1.857-4.277, p ≤0.001); heterozygote (TC vs. CC: OR = 0.985, 95% CI 1.023-1.651, p = 0.032), dominant (TT+TC vs. CC: OR = 1.095, 95% CI 1.183-1.859, p = 0.001), and recessive (TT vs. TC+CC: OR = 1.410, 95% CI 1.575-3.445, p ≤0.001), but not in Caucasians (Table 2). The gene discussed is MTHFR; the disease is ovarian cancer.