HIF1A and neoplasm: Interestingly, Parks and coauthors suggested a possible function of HIF1 in the metabolic adaptation of aerobic glycolysis [27], a finding that is in line with the association of HIF1-mediated transcriptional upregulation of glycolytic genes in a tumor model of Drosophila [25]; in this tumor model, the glycolytic genes were upregulated, not only by the HIF1 associated with hypoxia, but also due to the activity of HIF under normoxia, which seems to be responsible for the development of glycolytic tumors [25].