Since the CXCR4–CXCL12-axis and hypoxic conditions have been linked to the BM metastasis of solid cancer [51,52,53] and based on xenograft experiments indicating a role for CXCR4 in bone marrow infiltration of DLBCL [10], it might be possible that this axis is also implicated in lymphoma progression and dissemination. This evidence concerns the gene CXCR4 and diffuse large B-cell lymphoma.