As decreased p11 expression in the hippocampus of rodents with depression-like phenotype is associated with reduced cell proliferation and a subsequent upregulation after three weeks of antidepressant treatment with fluoxetine correlates with a patients recovery, accumulating evidence hints at p11 to be involved in antidepressant-induced hippocampal neurogenesis [15,16]. The gene discussed is S100A10; the disease is depressive disorder.