HIF1A and breast adenocarcinoma: Overall, 4-substituted 1,2,3-triazole L-ASA conjugates were identified as a promising chemical entity that affected the HIF-1α signaling pathway, and further structure optimization of the saturated C4-C5(OH) derivatives could lead to a more potent and selective growth-inhibition effect on breast adenocarcinoma (MCF-7) cells.