The complex interplay of pro- and anti-inflammatory cytokines (e.g., IL-6, IL-10, IL-13, tumor-necrosis factor (TNF-α), and oxytocin) and other pro- and anti-obesity-relevant peptides, especially leptin (LP), adiponectin (AN), and ghrelin (GH), are thought to evoke the genesis and maintenance of both chronic conditions (pain–metabolic disorder) [28,32,33,34,35,36,37,38,39]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.