PKM and esophageal cancer: Considering both that an increase in PKM2 phosphorylation at Tyr105 is positively associated with nuclear localization of PKM2 [58] and our data, ATP6V0C is likely to induce nuclear translocation of PKM2 by enhancing PKM2 phosphorylation at Tyr105, although the kinase responsible has not yet been identified in esophageal cancer cells.