On the other hand, drug development against Mycobacterium tuberculosis (Mt), despite the increased occurrence of multiple drug resistant (MDR-TB) and extensively drug resistant (XDR-TB) strains, has reached a noticeable progress on inhibitor design against 2-trans enoyl-acyl carrier protein reductase (InhA), the most frequently addressed validated mycobacterial drug target. The gene discussed is INHA; the disease is tuberculosis.