TP53 and colorectal carcinoma: While SW480 carries the characteristics of mismatch-proficient CRC lines with mutations in APC, K-ras and p53 and loss of heterozygosity at chromosomal locations of tumor suppressor genes [37,38], HCT116 cells are mismatch-repair deficient and carry mutations in β-catenin and the TGFβ receptor [38].