Studies by Komatsud et al. indicated that TLR-2 mRNA levels significantly increased in the peripheral blood of SLE patients compared to the control group, whereas Kirchner et al. demonstrated that the level of TLR-4 expression on CD14 + monocytes was significantly lower in patients with SLE compared to the control group [19,20]. This evidence concerns the gene TLR4 and systemic lupus erythematosus.