A large number of genetic alterations (> 200) have been identified in human NSCLC; for example, the v-Ki-ras2 Kirsten rat sarcoma virus oncogene (KRAS) and epidermal growth factor receptor (EGFR) are the most commonly mutated oncogenes that drive the pathogenesis of lung cancer [33,34,35]. The gene discussed is KRAS; the disease is lung carcinoma.