Autophagy also has been suggested to attenuate DEDD (death-effector domain-containing DNA-binding protein)-induced EMT by inducing the degradation of Snail and Twist in breast cancer cell lines [59] or by degrading Snail in lung or cervical cancer cell lines [61], or during TGFβ-induced EMT in immortalized hepatocytes in a p62-dependent manner [62]. This evidence concerns the gene SQSTM1 and breast cancer.