TGFβ has also been shown to induce CSC marker expression in different types of cancers [84], and TNFα and IL-6 can synergistically activate the TGFβ signaling pathway through activation of NF-κB, the activation of which also induces the expression of EMT-TF and IL-6 secretion [69,85]. The gene discussed is TGFB1; the disease is cancer.