For instance, autophagy has been shown to be necessary for EMT induction in a model of DRAM1 (a p53-mediated regulator of autophagy)-mediated EMT, invasion, and metastasis in hepatoblastoma cells [52], as well as for TGFβ2-induced EMT and reactive oxygen species (ROS) modulation in hepatocellular carcinoma [51], or for TGFβ1-induced EMT in non-small-cell lung carcinoma (NSCLC) cell lines [54]. The gene discussed is DRAM1; the disease is non-small cell lung carcinoma.