IGF1 and inflammatory bowel disease: Recent studies have demonstrated the crucial role of the Insulin-like Growth Factor 1/ PhosphoInositide 3 Kinase/ Protein Kinase B/ Mammalian Target of Rapamycin (IGF1/PI3K/Akt/mTOR) axis dysregulation associated with reduction of IGF1-R in muscle specimens of patients with IBD [12].