However, the effects of miR-335 inhibitor on FTY720 induced ROS generation were not reversed by knocking down SOD2 in NSCLC cells (Figure 7H, 7I), which indicated that FTY720 might regulate oxidative stress in NSCLC cells by targeting miR-335 in a SOD2 independent way. Here, SOD2 is linked to non-small cell lung carcinoma.