That can be explained by the ROS-independent electrophilic reactivity of CD with Keap1/Nrf2, subsequently resulting in HO-1 expression [42,70,95], but does not explain the selective cytotoxicity of CD on the A375 tumor cells as the normal (healthy) cells did not show a CD initiated and apoptosis mediated cytotoxicity. Here, HMOX1 is linked to neoplasm.