For example, the CASP3 gene encodes a cysteine-aspartic acid protease that served to as an apoptosis executor, and has been linked with cataract in rat[34–35]; HMGB1 plays an important role in protecting the keratinocytes from ultraviolet radiation-induced cell death and is thus involved in cataract formation[36]. The gene discussed is CASP3; the disease is cataract.