TOP2B and atherosclerosis: Those were Epithelial cell signaling in Helicobacter pylori infection (ATP6V1C1 and CASP3, both were hypermethylated), Platinum drug resistance (TOP2B, GSTM3, and CASP3, all were hypermethylated), Viral myocarditis (LOC100463889 and CASP3, both were hypermethylated), Fluid shear stress and atherosclerosis (LOC100484313, GSTM3, and ACVR2A, all were hypermethylated), Chemical carcinogenesis (GSTM3, hypermethylated) (Fig 5, Table 4 and S3 Table).