However, the fact that human Th17 cells are responsible for the inflammatory cell infiltration in gastrointestinal mucosa and the high expression of IL-17 in patients with inflammatory bowel disease (Ulcerative colitis and Crohn’s disease) implicates the gut residential Th17 cells’ involvement in chagasic megacolon [55–57]. The gene discussed is IL17A; the disease is Crohn disease.