CRP and appendicitis: Fig 3 shows the results of the respective analysis. ROC curves for diagnosis of acute appendicitis and complicated appendicitis demonstrate increased areas under the curve (AUCs) (Fig 3A and 3D). At selected cut-off points, the properties of the biomarker signatures were compared to those for CRP, leukocytes and neutrophils (Fig 3B, 3C, 3E and 3F). For both diagnostic applications the properties of the biomarker signatures outperform those of the conventional single lab values. Tables 3 and 4 show the exact values for AUCs as well as properties at the cut-off points.