The ANK3 gene encodes ankyrin-G, a protein that has been shown to regulate the assembly of voltage-gated sodium channels and is essential for normal synaptic function.48ANK3 is one of strongest and most replicated genes for bipolar disorder,32 and variants within ANK3 have also been associated in the Psychiatric Genomics Consortium cross-disorder GWAS,49 and in a rare variant analysis of autism spectrum disorder.50 Here, ANK3 is linked to bipolar disorder.