P2RY12 and atrial fibrillation: This low rate of triple therapy in STEMI patients with AF has been reported in other studies, such as the APEX-AMI study, where 10.6% of new-onset AF patients hospitalized for STEMI were on triple therapy.15 Seventeen percent of patients in group 2 were on P2Y12 inhibitors other than clopidogrel and none of these were on anticoagulants at discharge.