Here, we show that mouse bone marrow-derived neutrophils cultured with either recombinant IFNλ or with conditioned medium from primary cultured RPE cells overexpressing IFNλ to simulate the increased IFNλ levels that we observe in the RPE of human AMD patients (Supplementary Fig. 6), exhibit increased levels of LCN-2 and phosphorylated STAT1 (Fig. 3a). Here, STAT1 is linked to age-related macular degeneration.