While not increased in 2-month-old Cryba1 cKO retina, by 4 months, when an AMD-like phenotype is apparent in this mouse model, CD45highCD11b+Ly6ChighLy6G+ neutrophils were increased nearly three-fold relative to Cryba1fl/fl control retinas, and continued to increase with age, as seen in the 13-month-old Cryba1 cKO retina with respect to aged control mice (Fig. 1a). The gene discussed is CRYBA1; the disease is age-related macular degeneration.