For example, using the established paradigm, the etiology of decreased cell to cell coupling, conduction slowing and reentry arrhythmias demonstrated in type 1b arrhythmias in pig was later demonstrated to be in part attributable to connexin 43 remodeling in rat model of ischemia, with changes in Cx43 localization, expression and phosphorylation (125). The gene discussed is GJA1; the disease is ischemia.