Finally, inactivation of one or both of the ATP-dependent chromatin remodelers Alpha-Thalassemia/mental Retardation X-linked (ATRX) and Death domain-Associated protein-6 (DAXX) are often found in ALT tumors (Heaphy et al., 2011; Lovejoy et al., 2012; Schwartzentruber et al., 2012). Here, DAXX is linked to alpha thalassemia spectrum.