In the case of DMBA-induced carcinogenesis, the mice possessing the 375A allele of Ahr, encoding the high-affinity ligand-binding receptor, develop skin cancers, but the mice possessing the 375V allele, encoding the low-affinity one do not (39); in contrast, there is another report demonstrating no significant differences in carcinogenesis between Ahr+/+ mice and Ahr−/−mice by topical application of DMBA (40). Here, AHR is linked to skin neoplasm.